La Plata R-II High School serves students in grades 9 through 12. The school offers guidance and counseling sessions. Its academic curriculum includes classes in language arts, science, math, social studies, and physical and technology education. La Plata R-II High School provides instructive sessions related to band and choir. The school offers sports activities, including basketball, softball, baseball, cheerleading, golf, and track and field. It maintains a drama and science club. La Plata R-II High School also has the BETA club. The school additionally maintains a student council. It has a media center that provides a variety of materials for study and research. It is governed by La Plata R-II Schools, which serves students in kindergarten through grade 12, as well as operates a preschool.